(19)

(11)

EP 1 699 819 A2

(12)

(88) Date of publication A3: 29.09.2005 (43) Date of publication: 13.09.2006 Bulletin 2006/37 (21) Application number: 04804488.7 (22) Date of filing: 29.12.2004

(51) International Patent Classification (IPC):  C07K 14/475(2006.01) (86) International application number: PCT/EP2004/014910 (87) International publication number: WO 2005/063807 (14.07.2005 Gazette 2005/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 29.12.2003 US 532993 P (71) Applicants: CENTELION 94400 Vitry Sur Seine (FR) Aventis Pharma S.A. 92160 Antony (FR)	(72) Inventors: UZAN, Andre F-75116 Paris (FR) CARON, Alexis F-94240 L'Hay les Roses (FR) (74) Representative: Lecca, Patricia S.  CENTELION 72-82, rue Léon Geffroy 94400 Vitry sur Seine 94400 Vitry sur Seine (FR)