(19)

(11)

EP 1 701 724 A2

(12)

(88) Date of publication A3: 15.09.2005 (43) Date of publication: 20.09.2006 Bulletin 2006/38 (21) Application number: 04815779.6 (22) Date of filing: 29.12.2004

(51) International Patent Classification (IPC):  A61K 31/4375(2006.01) (86) International application number: PCT/US2004/043777 (87) International publication number: WO 2005/067502 (28.07.2005 Gazette 2005/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: LV (30) Priority: 02.01.2004 US 533892 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)

(72) Inventors: GOBLE, Stephen, D. Rahway, New Jersey 07065-0907 (US) YANG, Lihu Rahway, New Jersey 07065-0907 (US) ZHOU, Changyou Rahway, New Jersey 07065-0907 (US) KOTHANDARAMAN, Shankaran Rahway, New Jersey 07065-0907 (US) GUIADEEN, Deodialsingh Rahway, New Jersey 07065-0907 (US) BUTORA, Gabor Rahway, New Jersey 07065-0907 (US) PASTERNAK, Alexander Rahway, New Jersey 07065-0907 (US) MILLS, Sander, G. Rahway, New Jersey 07065-0907 (US) (74) Representative: Man, Jocelyn  Merck & Co.,Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)