(19)

(11)

EP 1 705 992 A1

(12)

(43) Date of publication: 04.10.2006 Bulletin 2006/40 (21) Application number: 04703716.3 (22) Date of filing: 20.01.2004

(51) International Patent Classification (IPC):  A01N 63/00(2006.01) A61K 35/16(2006.01) A61K 35/14(2006.01) C12N 5/08(2006.01) (86) International application number: PCT/US2004/001612 (87) International publication number: WO 2005/079581 (01.09.2005 Gazette 2005/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (71) Applicant: Cedars-Sinai Medical Center Los Angeles, California 90048-1865 (US)	(72) Inventors: YU, John, S. Los Angeles, CA 90077 (US) BLACK, Keith Los Angeles, CA 90077 (US) EHTESHAM, Moneeb Nashville, Tennessee 37221 (US) (74) Representative: Banford, Paul Clifford et al Marks & Clerk, Sussex House, 83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)