(19)

(11)

EP 1 706 091 A1

(12)

(43) Date of publication: 04.10.2006 Bulletin 2006/40 (21) Application number: 05701782.4 (22) Date of filing: 05.01.2005

(51) International Patent Classification (IPC):  A61K 8/25(2006.01) A61Q 11/00(2006.01) A61K 8/26(2006.01) (86) International application number: PCT/GB2005/000011 (87) International publication number: WO 2005/065634 (21.07.2005 Gazette 2005/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 09.01.2004 GB 0400415 (71) Applicant: INEOS Silicas Limited Warrington, Cheshire, WA5 1AB (GB)

(72) Inventors: STANIER, Peter William Sandbach, Cheshire CW11 1ES (GB) ARAYA, Abraham Merseyside, Cheshire L63 3JX (GB) MCKEOWN, Ian Patrick Merseyside, Cheshire L19 3QZ (GB) CREETH, Jonathan Edward, GlaxoSmithKline Weybridge, Surrey KT13 ODE (GB) (74) Representative: Instone, Terry et al Lloyd Wise, McNeight & Lawrence Commenwealth House 1-19 New Oxford Street London WC1A 1LW Commenwealth House 1-19 New Oxford Street London WC1A 1LW (GB)