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(11)

EP 1 711 198 A2

(12)

(88) Date of publication A3: 29.12.2005 (43) Date of publication: 18.10.2006 Bulletin 2006/42 (21) Application number: 05706022.0 (22) Date of filing: 21.01.2005

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) C12N 15/06(2006.01) G01N 33/20(2006.01) C12N 15/00(2006.01) C12N 15/07(2006.01) (86) International application number: PCT/US2005/002023 (87) International publication number: WO 2005/072270 (11.08.2005 Gazette 2005/32)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 23.01.2004 US 538718 P (71) Applicants: THE ADMINISTRATORS OF THE TULANE UNIVERSITY EDUCATIONAL FUND New Orleans, Louisiana 70112-2699 (US) Xavier University of Louisiana New Orleans LA 70125-1098 (US) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) 75654 Paris Cédex 13 (FR)

(72) Inventors: KLASSEN, Bryan New Orleans, LA 70123-5902 (US) VERROUST, Pierre, J. Hôpital Tenon (FR) ALLEN, Patricia New Orleans, LA 70131 (US) HAMMOND, Timothy New Orleans, LA 70115 (US) (74) Representative: Roques, Sarah Elizabeth et al J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)