(19)

(11)

EP 1 713 460 A2

(12)

(88) Date of publication A3: 10.11.2005 (43) Date of publication: 25.10.2006 Bulletin 2006/43 (21) Application number: 04813928.1 (22) Date of filing: 10.12.2004

(51) International Patent Classification (IPC):  A61K 31/16(2006.01) A61P 35/00(2006.01) A61K 31/385(2006.01) (86) International application number: PCT/US2004/041678 (87) International publication number: WO 2005/058298 (30.06.2005 Gazette 2005/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 10.12.2003 US 528501 P (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, WI 53726 (US)	(72) Inventors: RAJSKI, Scott R. Madison, WI 53704 (US) WASSARMAN, David A. Middleton, WI 53562 (US) RESTITUYO, Jose A. Madison, WI 53711 (US) (74) Representative: Mays, Julie et al Barker Brettell, 10-12 Priests Bridge London SW15 5JE London SW15 5JE (GB)