<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.5//EN" "ep-patent-document-v1-5.dtd">
<ep-patent-document id="EP05703305B8W1" file="EP05703305W1B8.xml" lang="en" country="EP" doc-number="1717246" kind="B8" correction-code="W1" date-publ="20151007" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>......DE......GB....................................................................................</B001EP><B005EP>J</B005EP><B007EP>JDIM360 Ver 1.28 (29 Oct 2014) -  2999001/0</B007EP></eptags></B000><B100><B110>1717246</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20151007</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>05703305.2</B210><B220><date>20050105</date></B220><B240><B241><date>20060804</date></B241><B242><date>20090901</date></B242></B240><B250>ja</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>2004001427</B310><B320><date>20040106</date></B320><B330><ctry>JP</ctry></B330></B300><B400><B405><date>20151007</date><bnum>201541</bnum></B405><B430><date>20061102</date><bnum>200644</bnum></B430><B450><date>20150812</date><bnum>201533</bnum></B450><B452EP><date>20141222</date></B452EP><B480><date>20151007</date><bnum>201541</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07K  14/525       20060101AFI20050722BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  38/00        20060101ALI20070104BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61K  47/48        20060101ALI20070104BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>C12N  15/09        20060101ALI20070104BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>TNF-ANTAGONISTEN UND DIESE ALS WIRKSTOFF ENTHALTENDE TNF-INHIBITOREN</B542><B541>en</B541><B542>TNF ANTAGONISTS AND TNF INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT</B542><B541>fr</B541><B542>ANTAGONISTES DU TNF, ET INHIBITEURS DU TNF LES CONTENANT EN TANT QU'INGREDIENT ACTIF</B542></B540><B560><B561><text>EP-A- 0 486 908</text></B561><B561><text>EP-A- 0 563 714</text></B561><B561><text>EP-A2- 1 354 893</text></B561><B561><text>US-A- 5 606 023</text></B561><B562><text>ZHANG X M ET AL: "SITE-DIRECTED MUTATIONAL ANALYSIS OF HUMAN TUMOR NECROSIS FACTOR-ALPHA RECEPTOR BINDING SITE AND STRUCTURE-FUNCTIONAL RELATIONSHIP" JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 267, no. 33, 25 November 1992 (1992-11-25), pages 24069-24075, XP002922635 ISSN: 0021-9258</text></B562><B562><text>LOETSCHER H. ET AL.: 'Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive especificity for the 55-kDa or 75-kDa TNF receptors.' J. BIOL.CHEM. vol. 268, 1993, pages 26350 - 26357, XP002304715</text></B562><B562><text>TSUTSUMI Y. ET AL.: 'Phage hyomen teijiho o kushishita kinosei jinko tanpakushitsu no soshutsu to DDS eno tenkial.' DRUG DELIVERY SYSTEM. vol. 18, 2003, pages 536 - 544, XP002992180</text></B562><B562><text>OSTADE VAN X ET AL: "HUMAN TUMOR NECROSIS FACTOR MUTANTS WITH PREFERENTIAL BINDING TO AND ACTIVITY ON EITHER THE R55 OR R15 RECEPTOR", EUROPEAN JOURNAL OF BIOCHEMISTRY, BLACKWELL PUBLISHING, BERLIN, DE, vol. 3, no. 220, 1 January 1994 (1994-01-01), pages 771-779, XP008003605, ISSN: 0014-2956, DOI: 10.1111/J.1432-1033.1994.TB18678.X</text></B562><B565EP><date>20070418</date></B565EP></B560></B500><B700><B720><B721><snm>MAYUMI, Tadanori</snm><adr><str>Gurasuarina-Nishijin-Chuo 907
5-1-1, Kojidai</str><city>Nishi-ku, Kobe-shi, Hyogo 6512273</city><ctry>JP</ctry></adr></B721><B721><snm>TSUTSUMI, Yasuo</snm><adr><str>20-1, Shinkofudai 2-chome
Toyono-cho, Toyono-gun</str><city>Osaka 5630105</city><ctry>JP</ctry></adr></B721><B721><snm>NAKAGAWA, Shinsaku</snm><adr><str>4-1, Nishikinomoto 4-chome
Yao-shi</str><city>Osaka 5810045</city><ctry>JP</ctry></adr></B721><B721><snm>OHTA, Tsunetaka</snm><adr><str>2-3, Shimoishii 1-chome</str><city>Okayama-shi, Okayama 7000907</city><ctry>JP</ctry></adr></B721></B720><B730><B731><snm>National Institutes of Biomedical Innovation, 
Health and Nutrition</snm><iid>101532864</iid><irf>312339EP/JND/LW</irf><adr><str>7-6-8, Saito-Asagi 
Ibaraki-shi</str><city>Osaka 567-0085</city><ctry>JP</ctry></adr></B731><B731><snm>Mayumi, Tadanori</snm><iid>100174270</iid><irf>312339EP/JND/LW</irf><adr><str>Gurasuarina-Nishijin-Chuo 907, 
1-1, Kojidai 5-chome, Nishi-ku</str><city>Kobe-shi,
Hyogo 6512273</city><ctry>JP</ctry></adr></B731><B731><snm>Tsutsumi, Yasuo</snm><iid>100242824</iid><irf>312339EP/JND/LW</irf><adr><str>20-1, Shinkohudai 2-chome, 
Toyono-cho</str><city>Toyono-gun,
Osaka 563-0105</city><ctry>JP</ctry></adr></B731><B731><snm>Nakagawa, Shinsaku</snm><iid>100183700</iid><irf>312339EP/JND/LW</irf><adr><str>4-1, Nishikinomoto 4-chome</str><city>Yao-shi,
Osaka 581-0045</city><ctry>JP</ctry></adr></B731></B730><B740><B741><snm>Daniels, Jeffrey Nicholas</snm><sfx>et al</sfx><iid>100033084</iid><adr><str>Page White &amp; Farrer 
Bedford House 
John Street</str><city>London WC1N 2BF</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>DE</ctry><ctry>GB</ctry></B840><B860><B861><dnum><anum>JP2005000032</anum></dnum><date>20050105</date></B861><B862>ja</B862></B860><B870><B871><dnum><pnum>WO2005066206</pnum></dnum><date>20050721</date><bnum>200529</bnum></B871></B870><B880><date>20061102</date><bnum>200644</bnum></B880></B800></SDOBI>
</ep-patent-document>
