(19)

(11)

EP 1 718 284 A2

(12)

(88) Date of publication A3: 26.05.2006 (43) Date of publication: 08.11.2006 Bulletin 2006/45 (21) Application number: 05722688.8 (22) Date of filing: 31.01.2005

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) A61K 31/472(2006.01) A61P 9/10(2006.01) G01N 33/68(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/US2005/003312 (87) International publication number: WO 2005/075022 (18.08.2005 Gazette 2005/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 30.01.2004 US 769744 30.01.2004 US 769542 22.04.2004 US 830477 22.04.2004 US 829674 10.01.2005 US 642909 P (71) Applicant: Decode Genetics EHF. 101 Reykjavik (IS)	(72) Inventors: HELGADOTTIR, Anna IS-112 Reykjavik (IS) HAKONARSON, Hakon IS-109 Reykjavik (IS) GULCHER, Jeffrey, R. Lake Barrington, IL 60010 (US) GURNEY, Mark, E. Grand Rapids, MI 49506 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)