(19)

(11)

EP 1 718 298 A2

(12)

(88) Date of publication A3: 27.04.2006 (43) Date of publication: 08.11.2006 Bulletin 2006/45 (21) Application number: 05713450.4 (22) Date of filing: 14.02.2005

(51) International Patent Classification (IPC):  A61K 31/435(2006.01) C07D 211/06(2006.01) A61K 31/445(2006.01) (86) International application number: PCT/US2005/004529 (87) International publication number: WO 2005/079337 (01.09.2005 Gazette 2005/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 17.02.2004 US 545109 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)

(72) Inventors: CONDON, Shannon Rahway, New Jersey 07065-0907 (US) DEVINE, Paul Rahway, New Jersey 07065-0907 (US) GAUTHIER, DONALD, R., Jr. Rahway, New Jersey 07065-0907 (US) LIMANTO, John Rahway, New Jersey 07065-0907 (US) SZUMIGALA, Ronald, H., Jr. Rahway, New Jersey 07065-0907 (US) (74) Representative: Buchan, Gavin MacNicol  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)