(19)
(11) EP 1 718 734 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.05.2008 Bulletin 2008/21

(45) Mention of the grant of the patent:
24.10.2007 Bulletin 2007/43

(21) Application number: 05707594.7

(22) Date of filing: 23.02.2005
(51) International Patent Classification (IPC): 
C12N 5/06(2006.01)
A01K 67/027(2006.01)
 C12N 15/01(2006.01)
(86) International application number:
PCT/EP2005/001897
(87) International publication number:
WO 2005/080552 (01.09.2005 Gazette 2005/35)

(54)

METHODS FOR GENETIC DIVERSIFICATION IN GENE CONVERSION ACTIVE CELLS

VERFAHREN ZUR GENETISCHEN DIVERSIFIZIERUNG IN GENKONVERSION- AKTIVEN ZELLEN

METHODE DE DIVERSITE GENETIQUE DANS DES CELLULES CAPABLES DE CONVERSION GENIQUE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

(30) Priority: 23.02.2004 EP 04004062

(43) Date of publication of application:
08.11.2006 Bulletin 2006/45

(73) Proprietor: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
85764 Neuherberg (DE)

(72) Inventors:
  • BUERSTEDDE, Jean-Marie
    80807 München (DE)
  • ARAKAWA, Hiroshi
    80937 München (DE)

(74) Representative: UEXKÜLL & STOLBERG 
Patentanwälte Beselerstrasse 4
22607 Hamburg
22607 Hamburg (DE)


(56) References cited: : 
WO-A-00/22111
 WO-A-02/100998
   
  • SALE J E ET AL: "TDT-ACCESSIBLE BREAKS ARE SCATTERED OVER THE IMMUNOGLOBULIN V DOMAIN IN A CONSTITUTIVELY HYPERMUTATING B CELL LINE" IMMUNITY, CELL PRESS, US, vol. 9, no. 6, 1998, pages 859-869, XP000876807 ISSN: 1074-7613
  • DIAZ M ET AL: "EVOLUTION OF SOMATIC HYPERMUTATION AND GENE CONVERSION IN ADAPTIVE IMMUNITY" IMMUNOLOGICAL REVIEWS, MUNKSGAARD, XX, vol. 162, April 1998 (1998-04), pages 13-24, XP000940962 ISSN: 0105-2896
  • YELAMOS J ET AL: "Targeting of non-lg sequences in place of the V segment by somatic hypermutation" NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 376, no. 6537, 1995, pages 225-229, XP002211125 ISSN: 0028-0836
  • ARAKAWA HIROSHI ET AL: "Immunoglobulin gene conversion: Insights from bursal B cells and the DT40 cell line." DEVELOPMENTAL DYNAMICS, vol. 229, no. 3, March 2004 (2004-03), pages 458-464, XP009029478 ISSN: 1058-8388 (ISSN print)
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).