(19)

(11)

EP 1 718 971 A2

(12)

(88) Date of publication A3: 26.05.2006 (43) Date of publication: 08.11.2006 Bulletin 2006/45 (21) Application number: 05756623.4 (22) Date of filing: 28.02.2005

(51) International Patent Classification (IPC):  G01N 33/543(2006.01) G01N 33/53(2006.01) A61K 9/51(2006.01) (86) International application number: PCT/US2005/006355 (87) International publication number: WO 2005/098429 (20.10.2005 Gazette 2005/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 26.02.2004 US 788501 (71) Applicant: University of Florida Research Foundation, Inc. Gainesville, FL 32611 (US)

(72) Inventors: MELKER, Richard J. Gainesville, FL 32605 (US) SACKELLARES, James Chris Gainesville, FL 32608 (US) GOLD, Mark S. Gainesville, FL 32608 (US) DENNIS, Donn Michael Gainesville, FL 32608-4189 (US) MARTIN, Charles R. Gainesville, FL 32605 (US) STEWART, Jon, D. Gainesville, FL 32606 (US) (74) Representative: Perry, Robert Edward  Gill Jennings & Every LLP Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)