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(11)

EP 1 720 530 A2

(12)

(88) Date of publication A3: 20.04.2006 (43) Date of publication: 15.11.2006 Bulletin 2006/46 (21) Application number: 05702505.8 (22) Date of filing: 14.02.2005

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) C07K 14/72(2006.01) A61K 38/00(2006.01) A61K 39/00(2006.01) G01N 33/68(2006.01) (86) International application number: PCT/IB2005/000382 (87) International publication number: WO 2005/085867 (15.09.2005 Gazette 2005/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 27.02.2004 US 548719 P (71) Applicant: Pfizer, Inc. New York, NY 10017 (US)

(72) Inventors: TANIGUCHI,Y Pfizer Global Research and Development Aichi-ken 470-2393 (JP) KACHI, Hiroko Pfizer Global Research and Develop. Aichi-ken 470-2393 (JP) TOMOTOSHI, Kimihiko Pfizer Global Research&Develop Chita-gun Aichi-ken 470-2393 (JP) SHINJO, Katsuhiro Pfizer Global Research and Deve. Chita-gun Aichi-ken 49-2393 (JP) KOMADA, Tohru Pfizer Global Research and Develop. Chita-gun Aichi-ken47 0-2393 (JP) (74) Representative: Rudge, Andrew John  Pfizer Limited European Pharma Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)