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(11)

EP 1 720 559 A1

(12)

(43) Date of publication: 15.11.2006 Bulletin 2006/46 (21) Application number: 05722783.7 (22) Date of filing: 04.02.2005

(51) International Patent Classification (IPC):  A61K 35/66(2006.01) A61K 35/00(2006.01) (86) International application number: PCT/US2005/003765 (87) International publication number: WO 2005/077389 (25.08.2005 Gazette 2005/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 06.02.2004 US 542725 P 20.04.2004 US 563996 P (71) Applicant: The University of Chicago Chicago, Illinois 60637 (US)	(72) Inventors: CHANG, Eugene, B., The University of Chicago (MC6084), Chicago, IL 60637 (US) PETROF, Elaine, O., The University of Chicago (MC6084), Chicago, IL 60637 (US) (74) Representative: Luderschmidt, Schüler & Partner  Patentanwälte, John-F.-Kennedy-Strasse 4 65189 Wiesbaden 65189 Wiesbaden (DE)