ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILT..FIRO..CY..TRBGCZEEHUPLSK....IS..............................*JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification1720881CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120130116W173deBibliographieenBibliographyfrBibliographieEP05717846.9200503012006091120070511enenen040457520040301GB042639220041201GB2013011620130320061115200646201212122012502011120620130116201303C07D 487/04 20060101AFI20050921BHEP C07D 519/00 20060101ALI20050921BHEP A61K 31/5517 20060101ALI20050921BHEP A61P 35/00 20060101ALI20050921BHEP de11-HYDROXY-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPIN-5-ONDERIVATE ALS SCHLÜSSELZWISCHENPRODUKTE ZUR HERSTELLUNG C2-SUBSTITUIERTER PYRROLOBENZODIAZEPINEen11-HYDROXY-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPIN-5-ONE DERIVATIVES AS KEY INTERMEDIATES FOR THE PREPARATION OF C2 SUBSTITUTED PYRROLOBENZODIAZEPINSfrDERIVES DE 11-HYDROXY-5H-PYRROLO[2,1-C][1,4] BENZODIAZEPINE-5-ONE EN TANT QU'INTERMEDIAIRES CLES POUR LA PREPARATION DE PYRROLOBENZODIAZEPINES SUBSTITUEES C2WO-A-00/12508WO-A-2004/043963CHEN ET AL: "A novel approach to the synthesis of cytotoxic C2?C3 unsaturated pyrrolo[2,1-c][ and ]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 6, 27 February 2004 (2004-02-27), pages 1547-1549, XP002329273KANG ET AL: "Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine" CHEMICAL COMMUNICATIONS, vol. 14, 11 June 2003 (2003-06-11), pages 1688-1689, XP002329274GREGSON ET AL: "Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 14, 31 March 2003 (2003-03-31), pages 2277-2280, XP002329063COOPER ET AL: "Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents" CHEMICAL COMMUNICATIONS, vol. 16, 5 July 2002 (2002-07-05), pages 1764-1765, XP002329275GREGSON ET AL: "Synthesis of the first example of a c2-C3/C2?-C3?-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 21, 27 August 2001 (2001-08-27), pages 2859-2862, XP002329276GREGSON ET AL: "Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 16, 14 April 2000 (2000-04-14), pages 1849-1852, XP004216014FUKUYAMA ET AL: "Total synthesis of (+)-porothramycin B" TETRAHEDRON LETTERS, vol. 34, no. 16, 16 April 1993 (1993-04-16), pages 2577-2580, XP002135999TIBERGHIEN ET AL: "Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 20, 1 September 2004 (2004-09-01), pages 5041-5044, XP00232927710174003.3227001020100825HOWARD, Philip Wilson3 Westbourne Mews, The MaltingsSt Albans Hertfordshire AL1 1LSGBGREGSON, Stephen John6 Warepoint Drive, ThamesmeadLondon Greater London SE28 0HJGBSpirogen Sàrl101349529RJW/LP6397038Chemin de la Pacottaz 1 c/o Michael Forer, 1806St-Légier-La ChiésazCHWatson, Robert Jameset al100044895Mewburn Ellis LLP 33 Gutter LaneLondon EC2V 8ASGBATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEISITLILTLUMCNLPLPTROSESISKTRGB200500076820050301enWO20050852512005091520053720061115200646