(19)

(11)

EP 1 720 905 A2

(12)

(88) Date of publication A3: 02.03.2006 (43) Date of publication: 15.11.2006 Bulletin 2006/46 (21) Application number: 04813939.8 (22) Date of filing: 10.12.2004

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) A61K 39/00(2006.01) C12N 15/62(2006.01) (86) International application number: PCT/US2004/041690 (87) International publication number: WO 2005/058950 (30.06.2005 Gazette 2005/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 11.12.2003 US 592016 P (71) Applicant: SIDNEY KIMMEL CANCER CENTER San Diego, CA 92121 (US)	(72) Inventors: DEISSEROTH, Albert San Diego, CA 92121 (US) TANG, Yucheng San Diego, CA 92122 (US) ZHANG, Wei-Wei San Diego, CA 92130 (US) FANG, Xiang-Ming San Diego, CA 92130 (US) (74) Representative: Viering, Jentschura & Partner  Steinsdorfstrasse 6 80538 München 80538 München (DE)