(19)

(11)

EP 1 721 153 A2

(12)

(88) Date of publication A3: 29.12.2005 (43) Date of publication: 15.11.2006 Bulletin 2006/46 (21) Application number: 05732274.5 (22) Date of filing: 02.03.2005

(51) International Patent Classification (IPC):  G01N 30/12(2006.01) (86) International application number: PCT/US2005/006518 (87) International publication number: WO 2005/093405 (06.10.2005 Gazette 2005/40)

(84) Designated Contracting States: DE FR GB (30) Priority: 05.03.2004 US 550869 P 05.05.2004 US 568446 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN Ann Arbor, Michigan 48109-1280 (US)	(72) Inventors: HASSELBRINK, Ernest, F. Saline, MI 48176 (US) LIBARDONI, Mark Ann Arbor, MI 48103 (US) SACKS, Richard, D. Ann Arbor, MI 48103 (US) (74) Representative: Gahlert, Stefan et al Witte, Weller & Partner Patentanwälte Postfach 10 54 62 70047 Stuttgart 70047 Stuttgart (DE)