(19)

(11)

EP 1 723 424 A2

(12)

(88) Date of publication A3: 15.06.2006 (43) Date of publication: 22.11.2006 Bulletin 2006/47 (21) Application number: 05736180.0 (22) Date of filing: 14.03.2005

(51) International Patent Classification (IPC):  G01N 33/566(2006.01) G01N 33/543(2006.01) A61K 35/00(2006.01) (86) International application number: PCT/US2005/008532 (87) International publication number: WO 2005/089308 (29.09.2005 Gazette 2005/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 12.03.2004 US 552909 P (71) Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION Columbus, Ohio 43210-1063 (US)	(72) Inventors: YOU, Ming St. Louis, MO 63141 (US) WANG, Min  (US) (74) Representative: Denison, Christopher Marcus  Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)