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EP 1 727 516 A1

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(43) Date of publication: 06.12.2006 Bulletin 2006/49 (21) Application number: 05732360.2 (22) Date of filing: 23.03.2005

(51) International Patent Classification (IPC):  A61K 8/67(2006.01) A61K 31/216(2006.01) A61Q 19/00(2006.01) A61Q 19/08(2006.01) A61K 8/37(2006.01) A61K 31/07(2006.01) A61Q 19/06(2006.01) A61Q 7/00(2006.01) (86) International application number: PCT/EP2005/003115 (87) International publication number: WO 2005/092283 (06.10.2005 Gazette 2005/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 26.03.2004 EP 04007281 (71) Applicant: DSM IP Assets B.V. 6411 TE Heerlen (NL)

(72) Inventors: SCHEHLMANN, Volker 79650 Schopfheim (DE) KLOCK, Jochen 79104 Freiburg (DE) MAILLAN, Philippe, Emmanuel F-68440 Eschentzwiller (FR) VOLLHARDT, Juergen, H. CH-4433 Ramlinsburg (CH) RAWLINGS, Anthony Northwich Cheshire CW9 8FH (GB) BEUMER, Raphael 79541 Loerrach (DE) (74) Representative: Best, Michael  Lederer & Keller Patentanwälte Prinzregentenstrasse 16 80538 München 80538 München (DE)