(19)

(11)

EP 1 729 798 A1

(12)

(43) Date of publication: 13.12.2006 Bulletin 2006/50 (21) Application number: 05729946.3 (22) Date of filing: 03.03.2005

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) (86) International application number: PCT/US2005/007036 (87) International publication number: WO 2005/102383 (03.11.2005 Gazette 2005/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 01.04.2004 US 558663 P 17.05.2004 US 571811 P (71) Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, CA 91125 (US)	(72) Inventors: YANG, Lili Pasadena, CA 91106 (US) BALTIMORE, David Pasadena, CA 91106 (US) (74) Representative: Muir, Benjamin M. J.  Beck Greener Fulwood House 12 Fuldwood Place London WC1V 6HR London WC1V 6HR (GB)