(19)

(11)

EP 1 729 800 A2

(12)

(88) Date of publication A3: 26.05.2006 (43) Date of publication: 13.12.2006 Bulletin 2006/50 (21) Application number: 05724183.8 (22) Date of filing: 02.03.2005

(51) International Patent Classification (IPC):  A61K 39/118(2006.01) C12P 21/04(2006.01) A61K 39/00(2006.01) C07H 21/04(2006.01) (86) International application number: PCT/US2005/006588 (87) International publication number: WO 2005/084306 (15.09.2005 Gazette 2005/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 02.03.2004 US 549832 P 12.01.2005 US 643110 P 19.01.2005 US 644552 P (71) Applicant: CHIRON CORPORATION Emeryville, California 94608-2916 (US)	(72) Inventors: GRANDI, Guido Emeryville, CA 94608 (US) GIULIO, Ratti Emeryville, CA 94608 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)