(19)

(11)

EP 1 730 178 A2

(12)

(88) Date of publication A3: 26.05.2006 (43) Date of publication: 13.12.2006 Bulletin 2006/50 (21) Application number: 05725582.0 (22) Date of filing: 15.03.2005

(51) International Patent Classification (IPC):  C07K 14/24(2006.01) C12N 15/81(2006.01) A61K 35/66(2006.01) C12N 15/31(2006.01) A61K 38/16(2006.01) A61K 31/04(2006.01) (86) International application number: PCT/US2005/008512 (87) International publication number: WO 2005/089812 (29.09.2005 Gazette 2005/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 15.03.2004 US 553209 P (71) Applicant: Iowa State University Research Foundation Ames, IA 50011 (US)	(72) Inventor: STAHL, Chad H., Ames, IA 50010 (US) (74) Representative: Tomkinson, Alexandra  Bailey Walsh & Co 5 York Place Leeds LS1 2SD Leeds LS1 2SD (GB)