(19)

(11)

EP 1 730 188 A2

(12)

(88) Date of publication A3: 01.12.2005 (43) Date of publication: 13.12.2006 Bulletin 2006/50 (21) Application number: 05717793.3 (22) Date of filing: 25.02.2005

(51) International Patent Classification (IPC):  C07K 14/575(2006.01) A61P 3/10(2006.01) A61K 38/22(2006.01) (86) International application number: PCT/GB2005/000710 (87) International publication number: WO 2005/082928 (09.09.2005 Gazette 2005/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 25.02.2004 GB 0404124 (71) Applicant: UNIVERSITY OF ULSTER County Londonderry BT52 1SA (GB)

(72) Inventors: GAULT, Victor, A., University of Ulster Coleraine, Co Londonderry BT52 1SA (GB) O'HARTE, Finbarr, Paul, Mary, University of Ulster Coleraine, Co Londonderry BT52 1SA (GB) FLATT, Peter, Raymond, University of Ulster Coleraine, Co Londonderry BT52 1SA (GB) IRWIN, Nigel, University of Ulster Coleraine, Co Londonderry BT52 1SA (GB) HARRIOT, Patrick, University of Ulster Coleraine, Co Londonderry BT52 1SA (GB) (74) Representative: O'Connell, Maura et al F. R. Kelly & Co., 4 Mount Charles Belfast, BT7 1NZ, Northern Ireland Belfast, BT7 1NZ, Northern Ireland (GB)