(19)

(11)

EP 1 732 539 A2

(12)

(88) Date of publication A3: 10.11.2005 (43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 05723505.3 (22) Date of filing: 18.02.2005

(51) International Patent Classification (IPC):  A61K 31/352(2006.01) A61P 35/04(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2005/005644 (87) International publication number: WO 2005/082355 (09.09.2005 Gazette 2005/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 20.02.2004 US 545917 P (71) Applicant: ARQULE, INC. Woburn, MA 01801-5140 (US)	(72) Inventors: LI, Chiang J. West Roxbury, MA 02132 (US) LI, YouZhi Westwood, MA 02090 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)