(19)

(11)

EP 1 732 580 A2

(12)

(88) Date of publication A3: 26.10.2006 (43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 04809990.7 (22) Date of filing: 15.10.2004

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61K 39/395(2006.01) A01N 37/18(2006.01) A01N 65/00(2006.01) A61K 31/70(2006.01) A01N 63/00(2006.01) A01N 43/04(2006.01) (86) International application number: PCT/US2004/034693 (87) International publication number: WO 2005/067460 (28.07.2005 Gazette 2005/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 24.12.2003 US 532696 P 18.08.2004 US 602588 P 01.10.2004 US 615548 P 07.10.2004 US 617564 P (71) Applicant: MEDIMMUNE, INC. Gaithersburg, MD 20878 (US)	(72) Inventor: KINCH, Michael, S. Laytonsville, MD 20882 (US) (74) Representative: Chapman, Paul Gilmour  Marks & Clerk 19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)