(19)

(11)

EP 1 732 588 A2

(12)

(88) Date of publication A3: 16.03.2006 (43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 05761976.9 (22) Date of filing: 05.04.2005

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) A61P 37/02(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2005/011487 (87) International publication number: WO 2005/097160 (20.10.2005 Gazette 2005/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 05.04.2004 US 559919 P 01.06.2004 US 576242 P 07.03.2005 US 659678 P (71) Applicant: The Regents of the University of California Oakland, CA 94607 (US)	(72) Inventors: LANIER, Lewis, L. San Francisco, CA 94127 (US) OGASAWARA, Koetsu San Francisco, CA 94122 (US) BLUESTONE, Jeffrey, A. San Francisco, CA 94103 (US) (74) Representative: Glawe, Delfs, Moll  Patent- und Rechtsanwälte, Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)