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(11)

EP 1 732 592 A1

(12)

(43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 05723536.8 (22) Date of filing: 23.02.2005

(51) International Patent Classification (IPC):  A61K 38/22(2006.01) A61P 19/00(2006.01) A61K 38/31(2006.01) (86) International application number: PCT/US2005/005691 (87) International publication number: WO 2005/082403 (09.09.2005 Gazette 2005/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 24.02.2004 US 547194 P (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, Wisconsin 53705-7365 (US)	(72) Inventors: VANDERBY, Ray Madison, WI 53705 (US) DWYER, Kelley Madison, WI 53715 (US) (74) Representative: Tollett, Ian et al Williams Powell Morley House 26-30 Holborn Viaduct London EC1A 2BP London EC1A 2BP (GB)