(19)

(11)

EP 1 732 629 A2

(12)

(88) Date of publication A3: 06.04.2006 (43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 05736314.5 (22) Date of filing: 25.03.2005

(51) International Patent Classification (IPC):  A61M 5/315(2006.01) (86) International application number: PCT/US2005/010206 (87) International publication number: WO 2005/097233 (20.10.2005 Gazette 2005/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 30.03.2004 US 557545 P 21.12.2004 US 638027 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: JACOBS, Alexander, Thomas Cambridge, MA 02141 (US) JUDSON, Jared, Alden Topsfield, MA 01983 (US) ROW, Gordon, Davidson Groton, MA 01450 (US) (74) Representative: Ingham, Stephen H.  Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor Sunninghill Road Windlesham, Surrey, GU20 6PH Windlesham, Surrey, GU20 6PH (GB)