(19)

(11)

EP 1 732 939 A2

(12)

(88) Date of publication A3: 16.02.2006 (43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 04815738.2 (22) Date of filing: 22.12.2004

(51) International Patent Classification (IPC):  C07H 21/04(2006.01) (86) International application number: PCT/US2004/043726 (87) International publication number: WO 2005/102379 (03.11.2005 Gazette 2005/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 07.04.2004 US 560649 P (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)	(72) Inventors: GARCIA, Pablo G. CHIRON CORPORATION Emeryville, CA 94608 (US) WILSON, Susan E. CHIRON CORPORATION Emeryville, CA 94608 (US) ZHANG, Gene Guozhong CHIRON CORPORATION Emeryville, CA 94608 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)