(19)

(11)

EP 1 733 052 A1

(12)

(43) Date of publication: 20.12.2006 Bulletin 2006/51 (21) Application number: 05732433.7 (22) Date of filing: 29.03.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) G01N 33/50(2006.01) (86) International application number: PCT/EP2005/003265 (87) International publication number: WO 2005/095643 (13.10.2005 Gazette 2005/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 30.03.2004 EP 04101306 (71) Applicant: F.HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventors: CLERC, Roger, G. CH-4102 Binningen (CH) GARDES, Christophe F-68870 Bartenheim (FR) MEYER, Markus 79395 Neuenburg (DE) WRIGHT, Matthew, Blake CH-4058 Basel (CH) (74) Representative: Witte, Hubert  Grenzacherstrasse, 124 4070 Basel 4070 Basel (CH)