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(11)

EP 1 735 001 A2

(12)

(88) Date of publication A3: 16.11.2006 (43) Date of publication: 27.12.2006 Bulletin 2006/52 (21) Application number: 05716230.7 (22) Date of filing: 19.03.2005

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) A61K 31/5517(2006.01) A61K 33/00(2006.01) A61P 17/00(2006.01) (86) International application number: PCT/EP2005/002947 (87) International publication number: WO 2005/089803 (29.09.2005 Gazette 2005/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 24.03.2004 EP 04007079 24.03.2004 EP 04007080 (71) Applicants: Boehringer Ingelheim International GmbH 55216 Ingelheim (DE) AT BE BG CH CY CZ DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR  Boehringer Ingelheim Pharma GmbH & Co. KG 55216 Ingelheim (DE) DE

(72) Inventors: HAYASHI, Tetsuo TOMISATO-SHI, Chiba 286-0201 (JP) KATSUYAMA, Shinichiro YOKOHAMA-SHI, Kanagawa 231-0845 (JP) OKADA, Minoru INZAI, Chiba 270-1323 (JP) UMEHARA, Norimitsu TOKOROZAWA-SHI, Saitama 359-0025 (JP) (74) Representative: Hammann, Heinz et al Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)