(19)

(11)

EP 1 735 442 A2

(12)

(88) Date of publication A3: 13.04.2006 (43) Date of publication: 27.12.2006 Bulletin 2006/52 (21) Application number: 05721546.9 (22) Date of filing: 18.03.2005

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61K 31/7088(2006.01) (86) International application number: PCT/JP2005/005619 (87) International publication number: WO 2005/090572 (29.09.2005 Gazette 2005/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 24.03.2004 US 555809 P (71) Applicant: Oncotherapy Science, Inc. Kawasaki-shi, Kanagawa 213-0012 (JP)	(72) Inventors: NAKAMURA, Yusuke Tokyo 1088639 (JP) NAKAGAWA, Hidewaki Tokyo 1088639 (JP) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)