(19)

(11)

EP 1 737 478 A2

(12)

(88) Date of publication A3: 23.03.2006 (43) Date of publication: 03.01.2007 Bulletin 2007/01 (21) Application number: 05728601.5 (22) Date of filing: 21.03.2005

(51) International Patent Classification (IPC):  A61K 36/00(2006.01) (86) International application number: PCT/US2005/009223 (87) International publication number: WO 2005/092016 (06.10.2005 Gazette 2005/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 19.03.2004 US 554968 P (71) Applicant: VANDERBILT UNIVERSITY Nashville, TN 37240 (US)	(72) Inventor: ENAN, Essam Nashville, Tennessee 37215 (US) (74) Representative: Strachan, Victoria Jane  Urquhart-Dykes & Lord LLP Alexandra House, 1 Alexandra Road Swansea SA1 5ED Swansea SA1 5ED (GB)