(19)

(11)

EP 1 740 547 A1

(12)

(43) Date of publication: 10.01.2007 Bulletin 2007/02 (21) Application number: 05733968.1 (22) Date of filing: 07.04.2005

(51) International Patent Classification (IPC):  C07D 215/44(2006.01) C07D 401/12(2006.01) A61P 29/00(2006.01) C07D 401/10(2006.01) A61K 31/4709(2006.01) (86) International application number: PCT/US2005/011643 (87) International publication number: WO 2005/100321 (27.10.2005 Gazette 2005/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 07.04.2004 US 560410 P (71) Applicant: MILLENNIUM PHARMACEUTICALS, INC. Cambridge, MA 02139 (US)

(72) Inventors: GHOSH, Shomir Brookline, MA 02446 (US) ELDER, Amy M. Arlington, MA 02474 (US) CARSON, Kenneth G. Princeton, NJ 08540 (US) SPROTT, Kevin T. Boston, MA 02129 (US) HARRISON, Sean J. Belmont, MA 02478 (US) HICKS, Frederick A. Somerville, MA 02143 (US) RENOU, Christelle C. Somerville, MA 02144 (US) REYNOLDS, Dominic Cambridge, MA 01239 (US) (74) Representative: Harris, Jennifer Lucy et al Kilburn & Strode 20 Red Lion Street GB-London WC1R 4PJ GB-London WC1R 4PJ (GB)