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EP 1 740 550 A1

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(43) Date of publication: 10.01.2007 Bulletin 2007/02 (21) Application number: 05728902.7 (22) Date of filing: 11.04.2005

(51) International Patent Classification (IPC):  C07D 233/84(2006.01) A61K 31/4164(2006.01) A61P 31/18(2006.01) C07D 401/12(2006.01) A61K 31/4439(2006.01) (86) International application number: PCT/IB2005/000969 (87) International publication number: WO 2005/100322 (27.10.2005 Gazette 2005/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 14.04.2004 GB 0408303 17.05.2004 US 571788 P 22.12.2004 GB 0428081 19.01.2005 US 645463 P (71) Applicants: Pfizer Limited Sandwich, Kent CT13 9NJ (GB) GB  Pfizer, Inc. New York, NY 10017 (US) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IS IT LI LT LU MC

(72) Inventors: JONES, L.H., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) MOHAMMED, S., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) MOWBRAY, C.E., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) NEWMAN, S.D., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) SELBY, M.D., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) STUPPLE, P.A., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) SWAIN, N.A., Pfizer Global Res. and Development Sandwich, Kent CT13 9NJ (GB) (74) Representative: Lane, Graham Mark Hamilton  Pfizer Limited European Patent Department Ramsgate Road Sandwich CT13 9NJ Ramsgate Road Sandwich CT13 9NJ (GB)