(19)

(11)

EP 1 742 632 A2

(12)

(88) Date of publication A3: 29.12.2005 (43) Date of publication: 17.01.2007 Bulletin 2007/03 (21) Application number: 05768713.9 (22) Date of filing: 25.03.2005

(51) International Patent Classification (IPC):  A61K 31/496(2006.01) A61P 25/00(2006.01) A61P 25/16(2006.01) A61N 1/30(2006.01) (86) International application number: PCT/EP2005/051401 (87) International publication number: WO 2005/107754 (17.11.2005 Gazette 2005/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: HR LV (30) Priority: 26.03.2004 US 556375 P 26.03.2004 EP 04101253 (71) Applicant: Solvay Pharmaceuticals B.V. 1381 CP Weesp (NL)

(72) Inventors: BOUWSTRA, Johanna A., SOLVAY PHARMACEUTICALS IPSI 1381 CP Weesp (NL) VAN DEN BERG, Dirk-J., SOLVAY PHARMACEUTICALS IPSI 1381 CP Weesp (NL) VERBAAN, Frederik J., SOLVAY PHARMACEUTICALS IPSI 1381 CP Weesp (NL) CONJEEVARAM, R.V., Solvay Pharmaceuticals Inc. Marietta, Georgia GA 30062 (US) BANGA, Ajay K. Atlanta, Georgia GA 30341-4155 (US) VEMULAPALLI, Viswatej Atlanta, Georgia GA 30341-4155 (US) VAN SCHARRENBURG, J., M. Solvay Pharmaceuticals 1381 CP Weesp (NL) TEUNISSEN, Hendrik Solvay Pharmaceuticals 1381 CP Weesp (NL) (74) Representative: Verhage, Marinus et al Octrooibureau Zoan B.V. P.O. Box 140 1380 AC Weesp 1380 AC Weesp (NL)