(19)

(11)

EP 1 742 914 A1

(12)

(43) Date of publication: 17.01.2007 Bulletin 2007/03 (21) Application number: 05723791.9 (22) Date of filing: 24.02.2005

(51) International Patent Classification (IPC):  C07D 209/52(2006.01) C07K 5/08(2006.01) A61K 31/403(2006.01) A61P 31/12(2006.01) C07D 307/00(2006.01) C07D 491/04(2006.01) C07K 7/02(2006.01) A61K 31/407(2006.01) C07D 491/04(2006.01) C07D 209/00(2006.01) (86) International application number: PCT/US2005/006083 (87) International publication number: WO 2005/085197 (15.09.2005 Gazette 2005/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 27.02.2004 US 548423 P (71) Applicant: SCHERING CORPORATION Kenilworth, New Jersey 07033-0530 (US)	(72) Inventors: BOGEN, Stephane, L. Somerset, New Jersey 08873 (US) PAN, Weidong Somerset, New Jersey 08873 (US) RUAN, Sumei Green Brook, New Jersey 08812 (US) NJOROGE, F., George Warren, New Jersey 07059 (US) (74) Representative: Adams, Harvey Vaughan John  Mathys & Squire 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)