(19)

(11)

EP 1 745 042 A1

(12)

(43) Date of publication: 24.01.2007 Bulletin 2007/04 (21) Application number: 05734348.5 (22) Date of filing: 08.04.2005

(51) International Patent Classification (IPC):  C07D 405/06(2006.01) (86) International application number: PCT/CA2005/000544 (87) International publication number: WO 2005/097779 (20.10.2005 Gazette 2005/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 09.04.2004 US 821584 27.08.2004 US 928564 (71) Applicant: Neuromed Pharmaceuticals, Ltd. Vancouver, BC V6T 1Z4 (CA)	(72) Inventors: PAJOUHESH, Hassan Vancouver, British Columbia V6Z 2X8 (CA) PAJOUHESH, Hossein Burnaby, British Columbia V5H 1R2 (CA) DING, Yanbing Vancouver, British Columbia V6R 1W5 (CA) SNUTCH, Terrance, P. Vancouver, British Columbia V6S 1M1 (CA) (74) Representative: van Loon, C.J.J. et al c/o VEREENIGDE Johan de Wittlaan 7 2517 JR The Hague 2517 JR The Hague (NL)