(19)

(11)

EP 1 745 289 A2

(12)

(88) Date of publication A3: 13.04.2006 (43) Date of publication: 24.01.2007 Bulletin 2007/04 (21) Application number: 05737395.3 (22) Date of filing: 15.04.2005

(51) International Patent Classification (IPC):  G01N 33/535(2006.01) (86) International application number: PCT/US2005/012898 (87) International publication number: WO 2005/103698 (03.11.2005 Gazette 2005/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 19.04.2004 US 563340 P 20.04.2004 US 563779 P 26.04.2004 US 565364 P (71) Applicant: Charm Sciences Inc. Lawrence, MA 01843-1032 (US)	(72) Inventors: LAW, Say-Jong Westwood, MA 02090 (US) CHARM, Stanley, E. Boston, MA 02110 (US) SAUL, Steven, J. Arlington, MA 02174 (US) (74) Representative: Webb, Andrew John  J.A. Kemp & Co., 14 South Square, Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)