(19)

(11)

EP 1 746 982 A2

(12)

(88) Date of publication A3: 18.05.2006 (43) Date of publication: 31.01.2007 Bulletin 2007/05 (21) Application number: 05742909.4 (22) Date of filing: 29.04.2005

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) A61K 31/675(2006.01) A61K 31/198(2006.01) A61P 9/10(2006.01) A61P 25/28(2006.01) A61K 31/435(2006.01) A61K 31/404(2006.01) A61P 5/48(2006.01) A61P 3/06(2006.01) (86) International application number: PCT/IT2005/000248 (87) International publication number: WO 2005/105066 (10.11.2005 Gazette 2005/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 30.04.2004 IT MI20040876 (71) Applicant: UNIVERSITA'DEGLI STUDI DI MILANO 20122 Milano (IT)	(72) Inventors: CRESTANI, Maurizio I-20090 Cesano Boscone (IT) GODIO, Cristina I-28887 Omegna (IT) MITRO, Nico I-20135 Milano (IT) (74) Representative: Long, Giorgio et al Jacobacci & Partners S.p.A. Via Senato, 8 20121 Milano 20121 Milano (IT)