(19)

(11)

EP 1 746 984 A2

(12)

(43) Date of publication: 31.01.2007 Bulletin 2007/05 (21) Application number: 05746254.1 (22) Date of filing: 05.05.2005

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) (86) International application number: PCT/US2005/015846 (87) International publication number: WO 2005/107728 (17.11.2005 Gazette 2005/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 06.05.2004 US 568542 P (71) Applicant: Hofmann, Robert F. Austin, TX 78746-2432 (US)	(72) Inventor: Hofmann, Robert F. Austin, TX 78746-2432 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)