(19)

(11)

EP 1 746 993 A1

(12)

(43) Date of publication: 31.01.2007 Bulletin 2007/05 (21) Application number: 05742346.9 (22) Date of filing: 29.04.2005

(51) International Patent Classification (IPC):  A61K 31/44(2006.01) (86) International application number: PCT/US2005/014826 (87) International publication number: WO 2005/107750 (17.11.2005 Gazette 2005/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 29.04.2004 US 566491 P (71) Applicant: Andrx Labs Llc Davie, FL 33314 (US)	(72) Inventors: CHENG, Xiu-Xiu Weston, FL 33331 (US) CULLEN, Edward, I. Montvale, NJ 07645 (US) (74) Representative: W.P. Thompson & Co.  55 Drury Lane London WC2B 5SQ London WC2B 5SQ (GB)