(19)

(11)

EP 1 747 270 A2

(12)

(88) Date of publication A3: 26.01.2006 (43) Date of publication: 31.01.2007 Bulletin 2007/05 (21) Application number: 05743019.1 (22) Date of filing: 10.05.2005

(51) International Patent Classification (IPC):  C12N 9/78(2006.01) (86) International application number: PCT/IT2005/000271 (87) International publication number: WO 2005/108562 (17.11.2005 Gazette 2005/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 10.05.2004 US 569567 P (71) Applicant: FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR 20132 Milano (IT)	(72) Inventors: DEGANO, Massimo; c/o DIBIT San Raffaele I-20132 Milano (IT) GIABBAI, Barbara; c/o DIBIT San Raffaele I-20132 Milano (IT) (74) Representative: Capasso, Olga et al de Simone & Partners SpA Via V.Bellini 20 00198 Roma 00198 Roma (IT)