(19)

(11)

EP 1 747 296 A2

(12)

(88) Date of publication A3: 09.03.2006 (43) Date of publication: 31.01.2007 Bulletin 2007/05 (21) Application number: 05737536.2 (22) Date of filing: 19.04.2005

(51) International Patent Classification (IPC):  C12Q 1/70(2006.01) (86) International application number: PCT/NL2005/000286 (87) International publication number: WO 2005/100611 (27.10.2005 Gazette 2005/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 19.04.2004 EP 04076193 17.02.2005 EP 05075387 (71) Applicant: Academisch Medisch Centrum 1105 AZ Amsterdam (NL)	(72) Inventors: BELD, Marcellinus, Gualbertus, Hubertus, Maria NL-1187 JW Amstelveen (NL) BOOM, Willem, René NL-1098 RL Amsterdam (NL) SOL, Cornelis, Johannes, Andreas NL-1098 LR Amsterdam (NL) (74) Representative: van Loon, C.J.J. et al c/o VEREENIGDE Johan de Wittlaan 7 2517 JR The Hague 2517 JR The Hague (NL)