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(11)

EP 1 748 995 A1

(12)

(43) Date of publication: 07.02.2007 Bulletin 2007/06 (21) Application number: 05734404.6 (22) Date of filing: 27.04.2005

(51) International Patent Classification (IPC):  C07D 319/20(2006.01) A61P 25/00(2006.01) A61K 31/357(2006.01) C07D 405/06(2006.01) (86) International application number: PCT/EP2005/004479 (87) International publication number: WO 2005/105776 (10.11.2005 Gazette 2005/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: HR LV (30) Priority: 05.05.2004 US 568314 P (71) Applicant: F. HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventors: BERGER, Jacob Los Altos Hills, CA 94022 (US) ZHAO, Shu-Hai Sunnyvale, CA 94086 (US) (74) Representative: Wasner, Marita et al F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)