(19)

(11)

EP 1 751 178 A2

(12)

(88) Date of publication A3: 16.03.2006 (43) Date of publication: 14.02.2007 Bulletin 2007/07 (21) Application number: 05750800.4 (22) Date of filing: 03.06.2005

(51) International Patent Classification (IPC):  C07K 14/165(2006.01) C07K 16/10(2006.01) G01N 33/569(2006.01) A61K 48/00(2006.01) A61K 39/215(2006.01) C12Q 1/70(2006.01) A61K 39/42(2006.01) (86) International application number: PCT/EP2005/006512 (87) International publication number: WO 2005/118813 (15.12.2005 Gazette 2005/50)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 04.06.2004 US 860641 10.06.2004 US 578348 P (71) Applicants: INSTITUT PASTEUR 75724 Paris Cédex 15 (FR) HKU - Pasteur Research Centre Limited Hong Kong (CN)

(72) Inventors: ALTMEYER, Ralf Hong Kong (CN) NAL-ROGIER, Béatrice Jade Garden-Mid Levels Hong Kong (CN) CHAN, Cheman Provident Center-North Point Hong Kong (CN) KIEN, François Hong Kong (CN) KAM, Yiu, Wing Hong Kong (CN) SIU, Yu, Lam Chai Wan Hong Kong (CN) TSE, Kong, San Hong Kong (CN) STAROPOLI, Isabelle F-75014 Paris (FR) MANUGUERRA, Jean-Claude F-75018 Paris (FR) (74) Representative: Desaix, Anne et al Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber 75009 Paris 75009 Paris (FR)