(19)
(11) EP 1 751 272 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.04.2009 Bulletin 2009/16

(45) Mention of the grant of the patent:
17.12.2008 Bulletin 2008/51

(21) Application number: 04791706.7

(22) Date of filing: 15.10.2004
(51) International Patent Classification (IPC): 
C12N 1/20(2006.01)
A61K 31/535(2006.01)
 C12P 17/18(2006.01)
C12R 1/465(2006.01)
(86) International application number:
PCT/IB2004/003380
(87) International publication number:
WO 2005/038009 (28.04.2005 Gazette 2005/17)

(54)

PRODUCTION OF TACROLIMUS (FK-506) USING NEW STREPTOMYCES SPECIES

HERSTELLUNG VON TACROLIMUS (FK-506) UNTER VERWENDUNG NEUER STREPTOMYCES-SPEZIES

PRODUCTION DE TACROLIMUS (FK-506) AU MOYEN DE NOUVELLES ESPECES DE STREPTOMYCES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL HR LT LV MK

(30) Priority: 17.10.2003 IN DE12842003

(43) Date of publication of application:
14.02.2007 Bulletin 2007/07

(73) Proprietor: Ranbaxy Laboratories Limited
Gurgaon - 122001, Haryana (IN)

(72) Inventors:
  • KUMAR, Parveen
    Ambala, Haryana 134112 (IN)
  • SHARMA, Sunita
    New Delhi, Delhi 110091 (IN)
  • SHUKLA, Aniruddha
    New Delhi, Delhi 110070 (IN)
  • KUMAR, Sudeep
    Ghaziabad, Uttar Pradesh 201011 (IN)
  • MAURYA, Raj Kumar
    Ghaziabad, Uttar Pradesh 201010 (IN)
  • KATIAL, Vikas
    Noida, Uttar Pradesh 201303 (IN)
  • MITRA, Ashoke
    New Delhi, Delhi 110044 (IN)
  • GIGRAS, P., Shri Jagdish Chander Jitender Kumar
    Moradabad, Uttar Pradesh 244001 (IN)

(74) Representative: Cronin, Brian Harold John et al
CRONIN Intellectual Property Chemin de Précossy 31
1260 Nyon
1260 Nyon (CH)


(56) References cited: : 
US-A- 4 894 366
US-A- 5 194 378
 US-A- 5 116 756
US-A- 5 624 842
   
  • MOTAMEDI H ET AL: "The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506" EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 256, no. 3, 1998, pages 528-534, XP000906738 ISSN: 0014-2956
  • REYNOLDS K A ET AL: "Rapamycin, FK506, and ascomycin-related compounds" DRUGS AND THE PHARMACEUTICAL SCIENCES, vol. 82, no. 82, 1997, pages 497-520, XP000906777 ISSN: 0360-2583
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).