(19)

(11)

EP 1 753 882 A2

(12)

(88) Date of publication A3: 28.07.2005 (43) Date of publication: 21.02.2007 Bulletin 2007/08 (21) Application number: 04796566.0 (22) Date of filing: 27.10.2004

(51) International Patent Classification (IPC):  C12Q 1/70(2006.01) C07H 21/04(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2004/035690 (87) International publication number: WO 2005/045062 (19.05.2005 Gazette 2005/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 27.10.2003 US 514673 P (71) Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION Columbus, Ohio 43210-1063 (US)	(72) Inventors: YOU, Ming St. Louis, MO 63141 (US) ZHANG, Zhongqiu Watertown, CT 06795 (US) FUTAMURA, Manabu Tokyo 104-0045 (JP) (74) Representative: TBK-Patent  Bavariaring 4-6 80336 München 80336 München (DE)