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(11)

EP 1 755 586 A2

(12)

(88) Date of publication A3: 01.06.2006 (43) Date of publication: 28.02.2007 Bulletin 2007/09 (21) Application number: 05818191.8 (22) Date of filing: 28.04.2005

(51) International Patent Classification (IPC):  A61K 31/35(2006.01) A61K 31/167(2006.01) C07D 309/38(2006.01) A61K 31/435(2006.01) A61P 35/00(2006.01) C07D 213/69(2006.01) (86) International application number: PCT/US2005/014747 (87) International publication number: WO 2006/028523 (16.03.2006 Gazette 2006/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 29.04.2004 US 566882 P 03.06.2004 US 576444 P 21.03.2005 WO PCT/US2005/009277 (71) Applicants: The Regents of the University of California Oakland, CA 94607-5200 (US) Puerta, David T. San Diego CA 92126 (US) Cohen, Seth M. San Marcos CA 92069 (US) Lewis, Jana A. San Diego CA 92129 (US)

(72) Inventors: PUERTA, David, T. San Diego, CA 92126 (US) COHEN, Seth, M. San Marcos, CA 92069 (US) LEWIS, Jana, A. San Diego, CA 92129 (US) (74) Representative: Lucas, Brian Ronald et al Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)