(19)

(11)

EP 1 755 619 A2

(12)

(88) Date of publication A3: 01.12.2005 (43) Date of publication: 28.02.2007 Bulletin 2007/09 (21) Application number: 05740034.3 (22) Date of filing: 23.03.2005

(51) International Patent Classification (IPC):  A61K 31/70(2006.01) (86) International application number: PCT/EP2005/051364 (87) International publication number: WO 2005/089733 (29.09.2005 Gazette 2005/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 23.03.2004 EP 04101199 (71) Applicants: VIB vzw 9052 Zwijnaarde (BE) VRIJE UNIVERSITEIT BRUSSEL 1050 Brussel (BE)	(72) Inventors: BERGLUND, Jenny DK-2720 Vanlose (DK) BOUCKAERT, Julie B-1640 Sint-Genesius-Rode (BE) DE GREVE, Henri B-1060 Brussel (BE) KNIGHT, Stefan S-75263 Uppsala (SE)