(19)

(11)

EP 1 756 304 A2

(12)

(88) Date of publication A3: 16.02.2006 (43) Date of publication: 28.02.2007 Bulletin 2007/09 (21) Application number: 05737635.2 (22) Date of filing: 20.04.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2005/013546 (87) International publication number: WO 2005/103299 (03.11.2005 Gazette 2005/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (30) Priority: 20.04.2004 US 563628 P (71) Applicant: Applied Research Systems ARS Holding N.V. Curacao (AN)	(72) Inventor: BLUME-JENSEN, Peter Newton, MA 02459 (US) (74) Representative: Sutcliffe, Nicholas Robert et al Mewburn Ellis LLP York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)